C.J. Spiller (shoulder) and Fred Jackson (knee) both returned from injuries and although Spiller did not miss any games, the dup needs to be productive in order for the Bills to challenge for an AFC East crown.
The Patriots are heavy favorites and should not struggle to win 11-plus games but why can’t the Bills win double figures as well?
Ryan Fitzpatrick has one of the weaker arms, but his accuracy and poise in the pocket can be special when he has a running game behind him.
Allowing 45 points in the second half was abysmal to witness, and the defense has always have given up their fair share of points before.
It will be imperative to stop the run since the Niners are run-oriented offense, but Alex Smith has made this team a much more balanced squad.
Randy Moss, Mario Manningham, Michael Crabtree and Vernon Davis should light up the Bills in crunch time although I am questioning Alex Smith in this contest.
Will he ever be a top 15 signal-caller in the NFL?
San Francisco has the elite of elite defenses, but they cannot afford a vanilla offense to secure a postseason home game and they need to finally breakthrough unlike last year.
C.J. Spiller is ready to go and he is electric when the ball is in his hands. Staying healthy and avoiding any big hits from the likes of Justin Smith, Navarro Bowman, Carlos Rogers, Patrick Willis, Donte Whitner or Dashon Goldson would be ideal.
Stevie Johnson and Scott Chandler remain the legit red zone threats in the passing game, and Buffalo should be able to hang in there for a few quarters until the pressure gets to them.
‘‘Nobody circles the wagons like the Buffalo Bills’’, and do not forget I had them making the playoffs this year. As much as I love their schedule in November and December, this is not a game where they should be able to pull off barring Alex Smith does his best Tony Romo and Matt Cassel Week 5 impersonation.
Network: CBS (714)
Time: 4:25 p.m. Eastern
Experts Pick: Niners by 9.5
Danny V’s Pick: Niners 30, Bills 17